THE OPENING: A NIH-funded Ph.D. student position is available on a pulmonary mechanics project in Biomedical Engineering.
THE PROBLEM: In the acute respiratory distress syndrome (ARDS), edema reduces pulmonary gas exchange. Mechanical ventilation assists gas exchange but causes ventilation induced lung injury (VILI) and impedes recovery.
OUR APPROACH AND FINDINGS: In isolated lungs, we made the first surface tension determinations in edematous alveoli. We find that VILI is attributable to heterogeneous lung mechanics, and proportional to surface tension. We have discovered a new property for two existing compounds – the ability to lower surface tension in the lungs.
THE PROJECT: Investigating the mechanism of action of the surface tension-lowering compounds and testing the compounds as treatments for VILI.
REQUIRED QUALIFICATION: An undergraduate degree in engineering or in a closely related discipline such as physics.
DESIRABLE QUALIFICATIONS: Background in cardiovascular or pulmonary mechanics, physiology or biophysics; experience with confocal microscopy or LabView programming.
THE PI: Carrie E. Perlman trained in mechanical engineering at MIT and biomedical engineering at Northwestern University. She was a postdoctoral fellow in pulmonary physiology at Columbia University.
THE ENVIRONMENT: Stevens, in Hoboken, NJ, provides a multidisciplinary research training environment. The beautiful campus is located on the Hudson River, directly opposite and 10 minutes by train from lower Manhattan.
CONTACT INFORMATION: Interested candidates should email Dr. Perlman at firstname.lastname@example.org, and attach a CV.