PhD students in mechanical engineering and bioengineering
Professor Sangpil Yoon is an assistant professor of Aerospace and Mechanical engineering and Bioengineering graduate program (https://engineering.nd.edu/profiles/syoon). Dr. Yoon started his lab starting August 1, 2018 at University of Notre Dame (https://www.sangpilyoon.com/) Yoon lab is recruiting two graduate students who will work with Dr. Yoon to accomplish multidisciplinary projects. Admissions for Spring 2019 or Fall 2019 will be available. Dr. Yoon is a NIH Pathway to Independence Award (K99/R00) recipient, so Yoon lab will be supported by National Institute of Health (NIH) for three years from now with $750,000 budget. Start-up funds over $1M from Notre Dame is also available.
The lab is located at Multidisciplinary Research Building on Notre Dame campus and approximately 1000 sq. ft space dedicated to the development of ultrasonic transducers and microfluidics and mechano-biology and cellular imaging research. The lab has two laminar flow cell culture bio cabinets, two CO2 incubators, and one inverted epifluorescence microscope with automated filter changers, automated stages, and EM-CCD camera in a dark room. Microplate readers and Real-Time PCR system are also available. Bacterial culture and incubators, gel readers, and Nanodrop spectrophotometer are equipped for cloning and molecular engineering purposes. On the other side of Yoon lab, high fidelity 3D translation stages with joystick and full ultrasound biomicroscope system for ultrasound imaging with high resolution are placed on anti-vibration tables. Parylene coating and stereoscopes are available for dissection and micrometer transducer fabrication. We are also considering buy Verasonics ultrasound scanner for future project.
Responsibilities and research projects as PhD students
1. Mechanical engineering part
Microfluidics chip development using Nanofabrication facility (NDNF) (https://www3.nd.edu/~ndnf/) on Notre Dame campus. It has equipment for dry etching and mask fabrication.
Micro-ultrasonic transducer development in Yoon lab and NDNF. Array type composite micrometer-sized ultrasonic transducer will be developed and characterized.
Ultra high frequency ultrasonic transducer development and characterization will be performed in Yoon lab. After the characterization, acoustic-tweezers and cell and biological effect of high frequency ultrasound will be investigated.
2. Molecular and cellular biology part
FRET biosensor development in Yoon lab will be performed for live cell imaging during stem cell reprogramming. Automated inverted microscope will be used. Cloning of new FRET biosensor and purification of proteins will be performed in Yoon lab. Imaging of cells during reprogramming using developed FRET BS and proteins will be performed.
Circulating tumor cell single cell tracing will be performed in Yoon lab. This project will be combined with part 1: mechanical engineering part. So students with engineering background or students with biology background who want to learn other side of technique and experience may have good chance to learn both fields. In this project, we are going to develop next generation contrast agents for CTC analysis and single cell tracing molecular tools.
Please directly email CV, names and email addresses of three references, and unofficial transcript (or copy of your transcript) to Sangpil Yoon (email@example.com). The deadline for Spring 2019 admission is October 21, 2018 and Fall 2019 is January 10, 2019.