Applications are now being sought for a postdoctoral research fellow to study mechanisms by which mechanical forces induce and regulate fetal cardiac morphogenesis, growth and remodeling. The Cardiovascular Developmental Bioengineering Laboratory at Cornell University, led by Prof. Jonathan Butcher, has pioneered the engineering of quantitative live imaging, biomechanical measurement, and mechanobiological stimulation systems to uniquely test rigorous hypotheses of how mechanosensitive switches operate to control morphogenetic decisions locally within the heart and its valves. His group has further developed multi-scale, multi-valent bioinformatics/computational strategies to model and predict mechanisms of morphogenesis that can be directly verified in vitro and in vivo. We incorporate both chick experimental and mouse genetic model systems, as well as utilize engineered emergent in vitro test platforms using primary cells. His lab has been continuously funded by the NIH and AHA for over 15 years, and publishes regularly in high impact journals. Further, his group collaborates with multiple complementary experts both at Cornell and around the world. Fellows will train with and help lead a dynamic transdisciplinary team while preparing themselves for their independent career.
This NIH funded position will pursue one or more of the following broad research goals: 1) Elucidate the in vivo mechanobiological regulatory network governing embryonic heart morphogenesis via localized hemodynamic perturbation in vivo, 2) Determine the interrelationships between growth factor signaling and mechanical stimulation in the normal and abnormal development of cardiac tissues. 3) Integrate the global and local biomechanical and molecular datasets in developing embryonic hearts towards a multi-scale computational model of ventricular and/or outflow tract morphogenesis.
Ideal candidates should have a PhD or equivalent degree with experience in live animal imaging, molecular biology/genetics, computational modeling, and/or 3D culture mechanobiology. Experience with cardiovascular and/or developmental biology is a plus. Interested candidates should forward a cover letter with a statement of their professional interests, a full CV, and a list of three references with complete contact information to:
Jonathan Butcher, PhD (email@example.com, www.butcherlab.com)
Meinig School of Biomedical Engineering