My research interests lie in the interface of engineering, nanotechnology and biology towards the utilization of the fundamentals of biomolecular recognition in the development of ultra sensitive diagnostic assays to meet the urgent and critical need for the early diagnosis of disease. My research includes the use of standard biophysical techniques such as, fluorescence anisotropy and SPR to acquire a mechanistic understanding of the details of antibody-antigen and DNA aptamer –protein recognition. It extends to the development of nanoparticle-based assays with main focus on optimizing surface chemistry for controlling specificity and fine tuning of the ligand-analyte detection schemes.
