Our laboratory investigates the role of mechanical forces on physiology, function and disease. In particular, we are interested in understanding the interaction between structure and mechanics in regulating biological responses at different length-scales. We will employ live cell imaging, cell/tissue mechanics and tissue engineering techniques to focus on several cardiovascular bioengineering problems including cardiac valve calcification, valve fusion and blood-brain barrier dysfunction. Knowledge gained from these studies will help guide the development of future medical interventions and regenerative therapies.