Mark Anastasio’s current research interests include the development of biomedical imaging methods, image reconstruction, and inverse problems in imaging and theoretical image science. His current research projects include the development of advanced X-ray, optical, and acoustical imaging systems that are based on wave physics and can provide important structural and physiological tissue information. These projects include photoacoustic and thermoacoustic imaging, X-ray phase-contrast imaging, optical and acoustical tomography and holography, and improvement of existing clinical imaging methods.