Esker's research interests focus on vertebrate paleontology, though if pushed he'll admit that many arthropods and cephalopods are pretty cool. He has particular interests in Jurassic sauropods, sphenodontians, and turtles, Pleistocene megafauna, tortoises of all ages, and the ecosystems of the Early Permian of Ohio. He uses multivariate analysis, stable isotope analysis, and photogrammetry in much of his research.